Description of Halofuginone

Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial acquired from the bulb Dichroa febrifuga, with antifibrotic and abeyant antineoplastic activities. Halofuginone accurately inhibits collagen blazon I gene announcement and cast metalloproteinase 2 (MMP-2) gene expression, which may aftereffect in the abolishment of angiogenesis, bump stromal corpuscle development, and bump corpuscle growth. These furnishings arise to be due to halofuginone-mediated inhibition of the collagen blazon I and MMP-2 promoters. Collagen blazon I and MMP-2 play important roles in fibro-proliferative diseases.
Halofuginone is a coccidiostat acclimated in veterinary medicine. It is a constructed halogenated acquired of febrifugine, a accustomed quinazolinone alkaloid which can be begin in the Chinese assemble Dichroa febrifuga (Chang Shan). Collgard Biopharmaceuticals is developing halofuginone for the analysis of scleroderma and it has accustomed drop biologic appellation from the U.S. Food and Biologic Administration.