Does Flibanserin Provide Real Sexual Benefits for Women?

The snowdrop, pushing its way up through melting snow, is a harbinger of spring. It also calls to mind a white-haired, bent-necked old lady pushing a walker through the slush. So it’s the perfect flower to represent the post-menopausal woman with HSDD. while the SNOWDROP trial’s results were remarkably similar to BEGONIA’s, SNOWDROP is perhaps most interesting for its exclusion criteria.
Women were excluded if they had “a history of a serious clinical disorder,” pelvic surgery such as hysterectomy, pelvic pain, endometriosis, urinary tract infection, or vaginal atrophy, or were taking medications such as any anti-depressants, benzodiazepines (anti-anxiety medications), prescription sleep aids, mood-stabilizers, anti-convulsants, and narcotics, among many others. The study required that women be monogamous, heterosexual, in a relationship for over a year, and have a sexually functioning partner who would be available for sexual activity for 50 percent or more of every month. Unsurprisingly, almost half the women screened for the study were not eligible to participate.
The exclusions were an attempt to isolate HSDD from other conditions that could cause sexual dysfunction, but they resulted in a study population far from representative of older women who wish to be more sexually active.
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