Experiments with levamisole hydrochloride in!

1.

Brazil would like to own diamond black and Sim ancient insecticide, decisively go to the pharmacy to buy two bottles of levamisole, 2 yuan a bottle that 100 decisively change the Sim ancient cylinder, drugging, 380 liters of water once I got 20, the next three consecutive days did not change the water during 3 days did not play worms found Xin Gumeng the eye, diamond black caudal fin, anal mild burning the end, but the state of the fish does not seem to discomfort, and then put oct Old groan large tank, as a light, was startled saw body is covered with a slight oct-old white flocculent object, these days the drug was apparently destroyed the protective mucus of fish body, the drug quickly scared I change the water tank full, the vats of water over to the inside, cotton, washed the whole ring, because the drug cylinder tube is bad, can not be clearly observed black diamond look, estimates and ancient Xin almost, I still tremble in fear, and do not know that drugs are not burnt fish offal, prayer not be any problem, here to remind you, if like me, put drugs, with or without effect, and quickly remove come. Prescription needs to be cautious, the fish accidentally hung up.

2.

Four dogs with natural infestation of Dirofilaria immitis were treated for 21 days with levamisole hydrochloride at dosages of 20 mg and 10 mg/kg bodyweight. Autopsy revealed at least 50% mortality of filaria. Signs of toxicity with the higher dosage disappeared after cessation of treatment.

Levamisole hydrochloride affects both circulating microfilaria (mf) (Mills & Amis, 1975) and adult filaria Dirofilaria immitis, and various dose regimes have been used with variable results, (Bradley & Alford, 1977; Garlick, 1976; Boring & Shepherd, 1974). This communication describes a pilot trial involving a 3 week oral dose schedule of levamisole hydrochloride at 20 mg and 10 mg active ingredient (ai)/kg body weight daily.