Induction of hepatic peroxisomes by a new, non-carbox

The astute aftereffect of an antimycotic drug, bifonazole, on hepatic peroxisomes of rats was advised in allegory with that of clotrimazole, which has a agnate structure. By agriculture 0.5% bifonazole in the diet for 5 days, the activities of camitine acyltransferase, carnitine palmitoyltransferase and the peroxisomal β-oxidation arrangement were added by 30-, 3- and 7-fold, respectively, over the control.
Under the aforementioned conditions, clotrimazole did not could cause such changes. Electron diminutive ascertainment showed that peroxisome admeasurement had been induced by bifonazole treatment. Thus, a admixture which does not accommodate a carboxylate atom can abet peroxisomes in rodent liver.