Oleamide and Cardiovascular Health

Blood Pressure

Acutely, injections of Oleamide that induce sleep and hypothermia fail to significantly affect blood pressure and heart rate

Endothelium

Oleamide is able to induce concentration and endothelium-dependent relaxation in arteries (0.01-10μM) with an EC50 of 350+/-260nM, with oleic acid and other FAAH metabolites not being involved in the observed vasorelaxation. These observed effects are mediated in part by the Cannabinoid Receptor 1 (CB1) and the non-CB1/CB2 antagonist O-1918 (Cannabinoid antagonist targeting other receptors) as well as TRPV1 (antagonist partially inhibited the effects of Oleamide) whereas elsewhere endothelial cells precontracted with an α-adrenergic agonist also noted vasorelaxation (EC50 of 1.2μM) but by mechanisms not related to the CB1 receptor and instead partially reliant on TRPV1 and nitric oxide.

Oleamide appears to have vasorelaxing properties, although it is uncertain how this practice affects the body. In looking at the potency in vitro, it is probably relevant to oral supplementation.