proglumide Mechanism of action

1, proglumide as a antagonist of gastrin, the substance structure of gastrin (G-17) and cholecystokinin (CCK) a couple of changjitai enterokinase zhongmo airport terminal chemical structure similar. Its functional groups amide-based certain properties and gastrin opposition around the wall of the gastrin receptor, which may significantly inhibit gastrin-induced intestinal, digestive, gastrointestinal acid and pepsin secretion, histamine and vagus sensors stimulation caused by digestive, gastrointestinal acid secretion Not evident. 2, can increase the particular content of gastric mucosal amino sugar, promote glycoprotein synthesis, the protection regarding the gastric mucosa package to promote healing, may improve the symptoms of peptic ulcer and promote ulcer healing. 3, typically the application of this device therapy of peptic ulcer and gastritis does not take place gastric acid secretion regarding the rebound phenomenon, following the termination of therapy can still make intestinal, digestive, gastrointestinal acid secretion in the normal level of half a dozen months. 4, can alleviate gastrointestinal smooth muscle spasm, pain, anti-inflammatory, peony, liquorice components containing anti-digestive ulcer substances. 5, items have the role of gallbladder; stimulate bile acid, change the bile into stone elements, antagonize CCK dilution bile.