Usage and dosage of sildenafil

1. For most patients, dosage of sildenafil is 50mg, taken about 1 hour before sexual activity, and sexual stimulation is required after taking the drug. However, it can be taken at any time within 0.5 to 4 hours before sexual activity. Based on the efficacy and tolerability, the daily dose can be adjusted between 25 and 100 mg, and the dosage should not exceed 1 time per day. (1) Dose of renal insufficiency The initial dose of 25% is recommended for patients with severe renal insufficiency (the AUC and cmax are almost doubled when the creatinine clearance is less than or equal to 30 ml/min). (2) The initial dose of liver dysfunction when the dose is recommended for liver damage (such as AUC and Cmax increased by 84% and 47%, respectively) is 25mg.

2. Elderly dose The recommended starting dose for elderly people over 65 years old is 25 mg.

3. Dosage for other diseases (1) The starting dose of a potent cytochrome P450 3A4 inhibitor and erythromycin is preferably 25 mg. (2) It is recommended that patients taking HIV protease to inhibit thorns (such as ritonavir) should not exceed 25 mg per day for sildenafil within 48 hours.

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