What is Ranolazine HCl

Ranolazine HCl should not be used with drugs like ketoconazole, clarithromycin, and nelfinavir that strongly inhibit CYP3A nor with drugs that activate CYP3A like rifampin and phenobarbital.
For drugs that are moderate CYP3A inhibitors like diltiazem, verapamil, erythromycin, the dose of Ranolazine HCl should be reduced
Some contraindications for Ranolazine HCl are related to its metabolism and are described under Drug Interactions. Additionally, in clinical trials Ranolazine HCl slightly increased QT interval in some patients and the FDA label contains a warning for doctors to beware of this effect in their patients.The drug's effect on the QT interval is increased in the setting of liver dysfunction; thus it is contraindicated in persons with mild to severe liver disease.