Chronic phenylmercuric acetate toxicity in a horse

Phenylmercuric acetate (PMA) was administered orally to a horse over a aeon of 27 weeks (190 days) at a dosage amount of 0.4 mg Hg/kg per day. The furnishings produced were constant with those of abiding asleep mercury intoxication. The analytic appearance included masseter beef atrophy, adversity in apperception and mastication, malodorous breath, bargain appetence and weight loss, and reflected cogent dissection changes involving the buccal, mandibular and dental tissues.
Renal dysfunction was axiomatic terminally and there was degeration and afterlife of the adjacent tubular epithelium. Necrotic and mineralized foci were begin in facial and masticatory msucles, splenic trabecuale and the myocardium. The axial afraid arrangement and the abdominal amplitude were unaffected. The almost beggarly claret asleep mercury assimilation was 500 ng/ml admitting amoebic mercury levels in claret were abundant lower.
The renal case had the accomplished asleep mercury content, three times greater than in the alarmist and cecum, while amoebic mercury was accomplished in those tissues and absent from the kidney. The aberration in the furnishings produced in this horse as compared to those in a horse accepting mercuric chloride at the aforementioned mercury dosage rate, could be attributed to the added accelerated and complete assimilation of Phenylmercuric acetate from the gastrointestinal tract.