Cytochrome b5, its functions, anatomy and film topology

The aboriginal allotment of the present advice reviews contempo advances in our compassionate of the accepted physiological functions of cytochrome b5. In addition, one area is adherent to a description of a afresh apparent action of cytochrome b5, namely its captivation in the amalgam of the oncofetal antigen N-glycolylneuraminic acid.

The additional allotment of the commodity summarizes site-directed mutagenesis studies, primarily conducted in the author's laboratory, in both the catalytic heme-binding and membrane-binding area of cytochrome b5.

These studies accept apparent that: 1) the film bounden area of cytochrome b5 spans the bilayer; 2) cytochrome b5 defective 19 COOH-terminal amino acids does not bind to film bilayers; and 3) specific amino acids in the film bounden area accept been mutated and apparent not to be capital for the action of cytochrome b5 with its redox partners.