Multifunctional pharmacology of flibanserin: accessible apparatus of ameliorative action in hypoactive animal admiration disorder

At clinically accordant doses, flibanserin acts predominantly at 5-HT(1A) receptors as an agonist and secondarily at 5-HT(2A) receptors as an antagonist. Additional bounden accomplishments aural an adjustment of consequence of its 5-HT(1A) affinity, which are not acceptable to be clinically relevant, cover weaker adversary accomplishments at 5-HT(2C) and 5-HT(2B) receptors, and beneath authentic action at dopamine (DA) D4 receptors.
Furthermore, the postsynaptic accomplishments of abiding flibanserin administering arise to authenticate a alternative for some populations of postsynaptic 5-HT receptors, decidedly those that are amid on the prefrontal case (PFC) cone-shaped neurons, which adapt monoamine absolution in assertive careful academician regions.
Conversely, flibanserin induces brief decreases in 5-HT levels in some academician areas such as the PFC, basis accumbens, and hypothalamus, but not in added academician areas such as the hippocampus. Therefore, back DA and NE are excitatory and 5-HT is inhibitory to animal admiration and arousal, it is appetizing to advance that the accomplishments of flibanserin on serotonin receptors at the PFC cone-shaped neurons, consistent in added DA and NE yet bargain 5-HT in the PFC, are the mechanistic underpinnings of acceptable animal admiration in HSDD.