Penfluridol: a neuroleptic biologic advised for continued continuance of action

Penfluridol is a unique, long-acting, articulate neuroleptic acceptance to the diphenylbutylpiperidines. The amalgam of penfluridol represented the aftereffect of a acceptable accurate seek for a awful lipophilic admixture structurally accompanying to haloperidol and pimozide.
Because of its abnormal lipophilicity, penfluridol distributes abundantly in blubbery tissues afterward articulate administration. This annex aftereffect produces a actual apathetic absolution of biologic from the tissues, and after-effects in a actual continued continuance of activity.
Penfluridol is abundantly metabolized by oxidative N-dealkylation to afford, as abandoned metabolites, the beta-glucuronide conjugate of the diphenylbutyric acerbic acquired A1 and the unconjugated basal piperidine atom B1. It is assumed, at this time, that the pharmacological action is attributable to the ancestor compound.
When administered clinically at articulate doses of 20 to 100 mg/week, penfluridol has been begin to be an able antipsychotic agent. This abundance of dosing is constant with the pharmacokinetic behavior of the biologic in man, and does not arise to aftereffect in any inappropriate accession of the biologic in patients. Wide variations in steady-state levels and claret abolishment half-life accept been empiric in accommodating populations.