HDAC3/NCOR2 (human recombinant)

Formula Weight : 49.7g/mol
Stability : 6 months
Formulation :
50 µg in 50 mM Tris-HCl, pH 8.0, containing 138 mM sodium chloride, 20 mM glutathione, and 10% glycerol
Description :
HDAC3 is a Class I HDAC which is related to the yeast HDAC Rpd3. It is primarily localized to the nucleus with ubiquitous distribution throughout human cell lines and tissues. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.
Purity : ≥50%
Storage : -80°C