NF-κB (p50) (human recombinant)

Stability : 6 months
Formulation : A solution in PBS, pH 7.4, containing 5 mM DTT and 20% glycerol
Description :
Members of this family are responsible for regulating over 150 target genes, including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. Because of this, NF-κB has often been called a 'central mediator of the human immune response. Acting as dimers, these transcription factors bind to 10 base pair DNA sequences, collectively called κB sites thereby regulating expression of target genes. The most common Rel/NF-κB dimer in mammals contains (p50)-RelA (p50/p65) heterodimers and is called NF-κB. The importance of Rel/NF-κB transcription factors in human inflammation and certain diseases makes them attractive targets for potential therapeutics.
Purity : >75%
Storage : -80°C