Cholic acid

Product Details

Name Cholic acid
Alias 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid
CAS  No. 81-25-4
Formula C24H40O5
Weight 408.57 g/mol
Usage Pharmaceuticals
Appearance Colorless flakes or white crystalline powder

Product Description

Cholic acid, also known since 3α, 7α, 12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble within alcohol and acetic acid), it is a white-colored crystalline substance. Salts of cholic acid are known as cholates. Cholic acid, together with chenodeoxycholic acid, is among the two major bile acids produced by the liver organ, where it is synthesized from cholesterol. These two major bile acids are roughly equal in focus in humans. Derivatives are usually made from cholyl-CoA, which usually exchanges its CoA with either glycine or taurine, yielding glycocholic and taurocholic acid, respectively.  Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting action in bile acid synthesis), and cholesterol does the particular opposite. This is why chenodeoxycholic acid, and not really cholic acid, can be utilized in order to treat gallstones (because lowering bile acid synthesis might supersaturate the stones also more).  Cholic acid plus chenodeoxycholic acid are the most crucial human bile acids. Other species may synthesize various bile acids as their main primary bile acids.

 

Function

Extracted from domestic animals (pig, cattle, sheep, rabbit) bile, an organic acid having a steroid structure, emulsify fat, promote digestion.

A sterol, one of the four most abundant bile acids in humans, from which glycocholic acid and taurocholic acid are the major bile acids in humans. The bile salts (sodium salts of bile acids) secreted by the liver into the bile are powerful emulsifiers. After the bile flows through the upper part of the small intestine, the bile salt emulsifies the fat to help it be digested and absorbed. After the fatty acid and glyceride of the emulsified fat droplets are absorbed by the lower part of the small intestine, the bile salt is also reabsorbed. They return to the liver and are reused, so bile salts always circulate between the liver and the small intestine. Bile salts are not only important for fat but also for all fat-soluble nutrients. When bile salt production or secretion defects occur due to certain diseases, undigested and unabsorbed fat appears in the feces. At this time, fat-soluble vitamins A, D, E, and K cannot be completely absorbed, and can cause a nutritional deficiency of vitamin A.

Cholic acid is synthesized by the liver and is discharged into the duodenum with bile. As one of the components of the digestive juice, it can promote the digestion and absorption of lipids. When the pyloric function is incomplete, bile acid will flow back into the stomach, causing damage to the gastric mucosa together with stomach acid, and causing stomach pain and other discomfort symptoms. Therefore, bile acid is one of the chemical factors that cause gastric mucosal damage. At present, in addition to neutralizing gastric acid, magnesium aluminocarbonate, which is commonly used in clinical practice, can also bind to bile acid, thereby reducing damage to the gastric mucosa, and is beneficial to the elimination of inflammation and the healing of ulcers.

After many patients with stomach pain, the symptoms of stomach pain will be relieved in a short period of time. However, it takes a certain time for the damaged mucous membrane to be completely repaired. For example, most ulcers require 4 to 6 weeks of regular treatment, which means symptoms. Elimination does not mean that the lesion has subsided, and it is necessary to give a continuation of medication for a certain period of time. At the same time, it is necessary to treat the cause of bile reflux. During treatment, you should also quit smoking, alcohol, avoid irritating foods such as coffee and tea, and use drugs that have damage to the gastric mucosa. Diet should be regular, avoid excessive stress and fatigue, for a small number of patients with anxiety and depressive symptoms. Advocate the appropriate medication.

Cholate is a fat emulsifier that aids in the hydrolysis and absorption of oils and fats in the intestines. Some bile acids also have the effects of strengthening the stomach, strengthening the stomach, and lowering the cholesterol content in the blood.

  • Treatment of cholecystitis, biliary deficiency, intestinal dyspepsia and other diseases.
  •  For many indications, including dissolution of gallstones and treatment and prevention of liver disease
  •  It is an organic and natural acid that can be used to produce vitamins D2 and D3.
  • The main pharmaceutical ingredients for artificial bezoar and hormone synthesis.

 

 

Application

Cholic acid, formulated as Cholbam capsules, is approved by america Food and Drug Administration being a treatment regarding children and grown ups with bile acid synthesis problems due to single chemical defects, and for peroxisomal disorders (such as Zellweger syndrome).

Main uses

  • A natural and organic acid solution having a steroid construction, which can emulsify fat and promote its digestive function
  • Emulsifier.
  • Used in biochemical research, pharmaceutical intermediates. Salt cholate is a choleretic drug for the treatment of cholecystitis, bile insufficiency, intestinal dyspepsia.
  • Non-denaturing ion detergent for extracting membrane proteins.

 


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