L-Arabinose

The application prospect of L-arabinose is broad:

First, the application of L-arabinose in baked goods.

L-arabinose has a stable molecular structure and is not decomposed at high temperatures, so it can be used in baked goods. Soft cookies are a kind of biscuits that Americans love, but they are high in sugar and easy to cause obesity. Therefore, adding L-arabinose to such biscuits can inhibit the absorption of sucrose and reduce the obesity of high-sugar biscuits. fear. Similarly, the addition of a certain amount of L-arabinose to baked goods such as cakes and egg yolks in high-calorie foods can reduce the unit energy density to attract more consumers. Since the molecular structure of L-arabinose contains an aldehyde group, it is a reducing monosaccharide. When it is mixed with sucrose to prepare a baked food, it will react with the amino acid, protein, and other substances in the dough to make a browning reaction. The flavor is more unique and the color is more beautiful. In addition, the amount of L-arabinose added in the baked food can generally be determined according to the actual situation, usually not more than 5%, and the addition of L-arabinose can affect the rheological properties, mouthfeel, processing technology, etc. of the dough, so that The baked goods produced are more delicious. Adding L-arabinose to fried foods such as fried chicken, roast chicken, grilled meat, etc. will give it a richer aroma and attractive color.

Second, the application of L-arabinose in beverages.

With the improvement of people's living standards, consumers' health awareness has gradually strengthened, and people's beverage structure has also undergone significant changes. The market for high-calorie beverages has been declining year by year, low-sugar drinks, sugar-free drinks, tea drinks, milk-containing drinks, plants. Nutritional, health-care, and functional beverages such as protein beverages, fruit, and vegetable juice beverages have gradually become the mainstream of the market. The addition of L-arabinose products in various beverages is in line with people's needs.

Third, the application of L-arabinose in biomedicine.

Hepatitis is one of the most prominent public health problems in the world. It is a serious disease that affects people's lives and causes related economic and social problems. Hepatitis virus is the main cause of hepatitis disease. There are six types of hepatitis viruses that have been classified so far. That is, the hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus, hepatitis E virus, and hepatitis G virus. Among them, the hepatitis B virus is the virus most infecting humans and the most harmful hepatitis virus. About 2 billion people worldwide have been infected with HBV. About 1 million people die each year from liver failure, liver cirrhosis and primary hepatocellular carcinoma (HCC) caused by HBV infection. Hepatitis C virus (HCV) also causes humans. One of the major viruses of acute hepatitis and chronic liver disease (including cirrhosis and liver cancer), it is estimated that 170 million people worldwide are chronically infected with HCV, 10 to 20% of them will develop cirrhosis, and 1 to 5% will be at 20%. After 30 years, it has developed into liver cancer. Therefore, hepatitis B caused by HBV and hepatitis C caused by HCV are the two most serious viral hepatitis in the world. It is precisely because of the serious harm of hepatitis B and hepatitis C. Among the current anti-hepatitis virus drugs, whether they are listed or under research, these two types of viral hepatitis are the main ones. L-arabinose can be used to synthesize antiviral drugs such as nucleoside analogs, and L-arabinose is used as raw material to synthesize 2-deoxy-2-fluoro-5-methyl-β-L-arabinofuranosyluracil ( L-FMAU). L-FMAU is an effective anti-hepatitis B virus (HBV) and anti-Ep-stein-Barr virus active agent. It is understood that there are five new anti-hepatitis B drugs in phase III clinical trials, two of which use L-arabinose as raw material: the new drug Clevudine (L-FMAU, pyrimidine nucleotide analogue) developed by Bukwang, Korea. The new drug Telbivudine (a type of L-nucleoside analogue) issued by Idenix Pharmaceuticals Inc. in the United States, two new antiviral drugs for the treatment of hepatitis B, telbivudine and koviffin, have been marketed in the United States and South Korea, respectively. The core structure is a nucleoside analogue derived from L-arabinose, which has the characteristics of specifically inhibiting hepadnavirus, not affecting DNA polymerase and mitochondrial function, high selectivity, low toxicity, etc. ,Market prospects.

Fourth, the application of L-arabinose in other fields.

Using L-arabinose as raw material, a rare sugar alcohol, arabitol, can be prepared by hydrogenation synthesis reaction for microbial fermentation and genetic improvement experiments. It can also be used to synthesize anti-AIDS, anti-viral and anti-cancer drugs. The important pharmaceutical intermediate - L-ribose; can also produce arabinose-reactive flavors that produce a soft, rich aroma.

Application field

Food and health products

• Diabetic food
• Diet food
• Healthy functional food
• Sucrose additive
• Healthy food

drug

• As a prescription for weight loss and blood sugar control
• Over-the-counter drug additive or drug-based excipient
• An ideal intermediate for the synthesis of flavors and fragrances
• As an intermediate in drug synthesis