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Nomegestrol acetate

Last modified
09/04/2018 - 07:37

Product Details

Name Nomegestrol acetate
Alias Nomegestrol 17-acetate / NOMAC
CAS  No. 58652-20-3
Formula C23H30O4
Weight 370.48 g/mol
Usage Pharmaceuticals
Appearance White Powder

Product Description

Nomegestrol Acetate is a new and highly effective oral progestin drug. In known steroidal oral contraceptives, norgestimate acetate has almost 100% oral contraceptive efficacy(NOMAC is well-absorbed, with an oral bioavailability of 63%.).

Nomegestrol Acetate(NOMAC) is used alone in the treatment of gynecological disorders including menstrual disturbances (eg, dysmenorrhea, menorrhagia, oligomenorrhea, polymenorrhea, amenorrhea ), vaginal bleeding, breast pain, and premenstrual syndrome and in menopausal hormone therapy.

Nomegestrol acetate ( NOMAC ), sold under the brand names Lutenyl and Zoely among others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.



Nomegestrol Acetate has an obvious inhibitory effect on pituitary gonads and inhibits ovulation. It has been proved by clinical trials to have a good contraceptive effect, minimally toxic and side effects, and convenient and safe use.

NOMAC has progestogenic activity, oligomenorrhea, effects, antiandrogenic activity, and no other polymenorrhea, hormonal activity.

It may be useful in helping to alleviate acne, seborrhea, and other androgen-dependent symptoms in women. It has some antiandrogenic activity and no other important hormonal activity.



Nomegestrol Acetate(NOMAC) is used by yourself inside the treatment of gynecological disorders including menstrual disorders (eg, dysmenorrhea, menorrhagia, oligomenorrhea, polymenorrhea, amenorrhea ), oral bleeding, breast pain, plus premenstrual syndrome as well as in menopausal hormone therapy. It truly is utilized in combination with estradiol like a birth control capsule and in menopausal body hormone therapy.

NOMAC has weak or moderate antiandrogenic activity (5 to 20 times less than that of cyproterone acetate (a strong antiandrogen), with approximately 12 to 31% of the RBA of testosterone for the androgen receptor ). However, Kuhl (2006, 2009) has reported that NOMAC has about 90% of the antiandrogenic activity of cyproterone acetate in rats, relative to 30 to 40% for dienogest.


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