Tadalafil

Last modified
09/11/2018 - 08:01

Product Details

Name Tadalafil
Alias Cialis
CAS  No. 171596-29-5
Formula C22H19N3O4
Weight 389.40 g/mol
Usage Pharmaceuticals
Appearance White crystalline powder

Product Description

Tadalafil is a second generation phosphodiesterase 5 inhibitors, an oral treatment of male erectile dysfunction drug, studies show, compared with sildenafil, Cialis onset is very rapid, about 15 ~ 20 min onset, the effect of long-term, up to 36h. T1/2 is 17.5h. In a 348 patients with mild to severe erectile dysfunction, male participation in the study, patients were randomized to tadalafil 20mg or placebo, results showed that compared with placebo, successful intercourse at 24 and 36 hours after dosing resistance are improved, the majority of male secondary sexual intercourse can occur successfully at 36 hours, and the incidence of adverse drug reactions and severity also no difference compared with placebo.

Other Name:cyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate; CHR2797-Tosedostat; CHR-2797; UNII-KZK563J2UW.

Function

Tadalafil is a PDE5 inhibitorThe inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP). 

Tadalafil is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Tadalafil is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.Tadalafil is an oral drug for the treatment of ED, used in the treatment of erectile dysfunction and premature ejaculation, erectile function impairment and premature ejaculation has very significant improvements. help both husband and wife a satisfactory sex life.

tadalafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.

 

Application

Tadalafil has been approximately 15,000 men participating in clinical trials and more than 8 million men worldwide (primarily in the post-approval / listing of the environment) and the use as a means of treatment of ED.

On November 21, 2003, the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil citrate ( Viagra ) and vardenafil (Levitra)).

Tadalafil was approved in May 2009 in the United States for the treatment of pulmonary arterial hypertension and is under regulatory review in other regions for this condition

On October 6, 2011, the US FDA approved tadalafil to treat the signs and symptoms of benign prostatic hyperplasia (BPH).

 

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