Chrysin derivative pharmacology

1. Anti-tumor

• *Anti-tumor cell proliferation
• *Inducing tumor cell apoptosis
• *Reversal of multidrug resistance in tumor cells
• *Anti-gene mutation

2. Radiotherapy sensitization
3. Hypoglycemic effect
4. Inhibition of aromatase activity
5. Free radical scavenging
6. Anti-inflammatory anti-bacterial and anti-virus
7. Antiplatelet antithrombotic

• 1) Chrysin inhibits ADP, collagen, thrombin and U46619-induced platelet aggregation.
• 2) Chrysin inhibits collagen-induced platelet activation and particle release.
• 3) Chrysin inhibits the number of platelets adhering to the cured collagen and reduces the area of individual platelet expansion. Chrysin reduces the expansion of platelets on the immobilized fibrinogen.
• 4) Western blot analysis showed that chrysin inhibited the phosphorylation of PLCY2 and decreased the activity of PKC. At the same time, chrysin inhibits Akt phosphorylation and ERK1/2 phosphorylation in the MAPK pathway. PI3K broad-spectrum inhibitor LY294002 combined with chrysin enhanced the inhibition of platelet aggregation.