Levamisole hydrochloride relevant literature

Alias of levamisole hydrochloride
Repellent hook; levamisole hydrochloride; levosimazole; levofloxacin; levothiazolidine, levamisole hydrochloride, levamisole

Pharmacological action of levamisole hydrochloride
It can inhibit the activity of succinate dehydrogenase in the muscles of the worm, causing the muscles to undergo continuous contraction and paralysis.

Molecular Formula and Molecular Weight of Levamisole Hydrochloride
C11H12N2S·HCl 240.76

Source (name), content (potency) of levamisole hydrochloride
This product is (S)-(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride. According to the dry product, the content of C11H12N2S·HCl should not be less than 98.5%.

Traits of levamisole hydrochloride
This product is white or off-white needle crystal or crystalline powder; odorless and bitter.

This product is very soluble in water, soluble in ethanol, slightly soluble in chloroform, and slightly soluble in acetone.

Melting point of levamisole hydrochloride
The melting point of this product is 225 ~ 230 °C.

Specific rotation of levamisole hydrochloride
Take the appropriate amount of this product, accurately weighed, dissolved in water and quantitatively diluted to make a solution containing about 50mg per 1ml. Determined according to law (Appendix VI E of the 2010 edition of the Pharmacopoeia), the specific rotation is not lower than -121.5 °.

Identification of levamisole hydrochloride
(1) Take about 60mg of this product, add 20ml of water to dissolve, add 2ml of sodium hydroxide test solution, boil for 10 minutes, let cool, add a few drops of sodium nitroferricyanide test solution, that is red; after placement, color The gradient is shallow.

(2) The infrared absorption spectrum of this product should be consistent with the control spectrum ("Infrared Spectral Collection of Drugs" 325).

(3) The identification reaction of the chloride in the aqueous solution of this product.

Examination of levamisole hydrochloride
3.7.1 clarity of the solution
Take this product 2.0g, add new boiling and cool to 20 ~ 25 ° C water 50ml, after dissolution, the solution should be clarified; such as turbid, and No. 2 turbidity standard solution.

Acidity of levamisole hydrochloride
The solution under the clarity of the solution is determined according to law, and the pH should be 3.5 to 5.0.

Absorbance of levamisole hydrochloride
Take this product, add hydrochloric acid-methanol titration solution (0.2mol / L) to make 1mg solution per 1ml, according to ultraviolet, measured at the wavelength of 310nm, the absorbance should not exceed 0.20.

Indications for levamisole hydrochloride
It is a broad-spectrum anthelmintic drug mainly used to drive mites and hookworms. Levamisole hydrochloride increases the patient's resistance to bacterial and viral infections. Currently used as adjuvant therapy after lung cancer, breast cancer surgery or acute leukemia, worsening lymphoma chemotherapy. In addition, it can be used for autoimmune diseases such as rheumatoid arthritis, lupus erythematosus, and upper sensation, pediatric respiratory infections, hepatitis, dysentery, sores, abscesses, and the like. The trial of refractory bronchial asthma has initially proved that the short-term effect is significant.