Stable under acidic condition, easy decomposition failure in alkaline condition. This product（Levamisole Hydrochloride \Levamisole HCL） is a tetramisole sinistral body, active about tetramisole (racemic form) 1 ~ 2 times, but a lower side effect.
White to light yellow crystalline powder, odorless, bitter. Melting point 227-229 ° C. Soluble in water, methanol, ethanol, and glycerin, slightly soluble in chloroform, ether; difficult to dissolve in acetone. It is stable under acidic conditions and easily decomposes under alkaline conditions.
It is obtained by resolution of racemicTetramisole Levamisole (C11H12N2S, [5036-02-2]), alkali precipitation, and salt formation. The bisbenzoyl-D-tartaric anhydride was boiled with water and hydrolyzed for 40 min. The temperature was lowered to about 45 ° C, the pH was adjusted to 7.5 with a sodium hydroxide solution, and racemic Tetramisole was added.
After half an hour of incubation, the temperature was lowered to 10 ° C, filtered, and washed with water to obtain levamisole-p-benzoyl tartrate. The pH was adjusted to 9 with sodium hydroxide solution, filtered, and washed with water to give levamisole. The pH was adjusted to 3-4 with hydrochloric acid, decolorized with activated carbon, filtered, and the filtrate was concentrated to dryness and then evaporated to 0 ° C with acetone. Crystallization is precipitated. Filtration and drying gave levamisole hydrochloride.
This product is an anthelmintic drug. Levamisole Hydrochloride (Levamisole HCL) is about twice as active as the racemate and has lower toxicity and side effects. Levamisole can be excreted with feces roundworm muscle paralysis. Mainly used for anti-aphids and anti-hookworms.
Formulation: levamisole hydrochloride tablets. It can be used as an immunopotentiator for autoimmune diseases such as recurrent and chronic infections caused by various pathogens, primary immunodeficiency diseases, rheumatoid arthritis, and lupus erythematosus. It can also be used as an adjuvant treatment for malignant tumors.
It is effective for lung cancer, breast cancer, and acute myeloid leukemia. It can be used after surgery, chemotherapy, and radiotherapy to consolidate the curative effect and reduce recurrence.
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