sulfacetamide mechanism of action

Sulfacetamide is a sulfonamide antiseptic. Sulfonamides are synthetic bacteriostatic antibiotics, that are energetic against gram-positive and gram-negative bacteria. It blocks typically the synthesis of dihydrofolic acid solution by inhibiting the enzyme dihydropteroate synthase. It will be a competitive inhibitor regarding bacterial para-aminobenzoic acid (PABA). PABA is required regarding bacterial synthesis of folic acid and it is an essential component regarding bacterial growth. The copie of bacteria is consequently inhibited by the action of sulfacetamide.

Sulfacetamide is usually absorped orally. The mouth absorption of sulfacetamide is found to be completely and the plasma protein holding is 80–85%. In typically the liver it is metabolized to inactive metabolites. Plasma half-life is 7 – 13. 8 hours.

Sulfonamides are generally metabolized by several oxidative pathways, acetylation, and conjugation with sulfate or glucuronic acid. Nevertheless , there are usually some dissimilarities in biotransformation between certain species. Acetylation, which reduces the solubility of sulfonamides, is for example poor developed in dogs. The acetylated, hydroxylated, and conjugated forms possess little antibacterial activity. In addition, the hydroxylated and conjugated forms are less probably to precipitate in pee. The hydrolysis takes place by the action of amidases.

It is excreted generally inside the urine. Secretory routes of less significance usually are bile, feces, milk in addition to sweat. Glomerular filtration, active tubular secretion, and tube reabsorption are the principle procedures involved.