Use of sulfacetamide

Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. When combined with sulfur, it is sold under the brand name names Plexion, Clenia, Prascion, and Avar, which contain 10% sulfacetamide and 5% sulfur.

Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor rosacea. It also has potent properties when used to treat blepharitis or conjunctivitis (in eye-drop solution). It is believed to work by restricting the reputation of folic acid which bacteria need to outlive. It has recently been suggested that sulfacetamide may also serve as a treatment for mild kinds of hidradenitis suppurativa.[citation needed] Sulfacetamide has antiseptic activity and is employed to control acne. Products that contains sulfacetamide and sulfur (a keratolytic) are commonly marketed for the treatment of acne rosacea (rosacea with papules, pustules, or both). There are several prescription topical products containing sulfacetamide, such as foams, shampoos, cream and washes.

Several research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism.