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Last modified
05/26/2018 - 08:27

Akt3 Monoclonal Antibody (Clone 66C1247.1)

Product Description

Formulation : 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% sodium azide and 0.05% BSA
Stability : 1 year
Storage : -20°C
Description :
WB · Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3-kinase and Akt/PKB kinase activity. There are three known isoforms of this enzyme in mammalian cells (1/a, 2/b, and 3/g). Akt1, 2, and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein. Akt/PKB phosphorylation is critical for its activity. 

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