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Last modified
05/26/2018 - 04:52


Product Description

CAS Number : 256498-66-5
Molecular Formula : C21H21FN8O
Formula Weight : 420.4g/mol
Specification :
Stability:2 years
Formulation:A crystalline solid
Description :
BAY-41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold. Surprisingly, NO donors synergize with BAY-41-8543 in stimulating recombinant sGC. BAY-41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations. In vivo, BAY-41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis.
Storage : -20°C

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