Last modified
05/26/2018 - 02:36

EX-527

Product Description

CAS : 49843-98-3
Molecular Formula : C13H13ClN2O
Formula Weight : 248.7g/ol
Specification :
Purity:≥98%
Stability:2 years
Description :
Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.
Formulation:A crystalline solid
Storage : -20°C
 

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