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Last modified
05/26/2018 - 02:24

GSK264220A

Product Description

CAS : 685506-42-7
Molecular Formula : C17H21N3O4S
Formula Weight : 363.4g/mol
Specification :
Purity:≥98%
Stability:2 years
Formulation:A crystalline solid
Description :
Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as substrate. GSK264220A is a potent inhibitor of endothelial lipase (IC50 = 16 nM). Levels of HDL cholesterol are inversely correlated with endothelial lipase protein activity. Therefore, inhibition of endothelial lipase by compounds like GSK264220A may be expected to increase HDL levels and potentially decrease the risk of cardiovascular disease. 
Storage : -20°C

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