Last modified
05/26/2018 - 09:02

Iressa

Product Description

CAS Number : 184475-35-2
Molecular Formula :C22H24ClFN4O3
Formula Weight : 446.9g/mol
Specification :
Formulation:A crystalline solid
Purity:≥98%
Stability:2 years
Description :
Overactivity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant growth.1 Iressa is a selective EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50s ranging between 0.2 - 0.4 µM.2 By interfering with the intracellular kinase domain, iressa prevents EGFR autophosphorylation and prevents downstream signal transduction. Iressa has been used to treat advanced (or recurrent) non-small cell lung cancer (NSCLC). However, the FDA retracted its general approval for this compound when a phase III trial failed to demonstrate an overall survival benefit.3 Iressa appears to be most efficacious in treating certain EGFR gene mutations that are prevalent in Asian populations.4,5 
Storage : -20°C

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