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Last modified
05/26/2018 - 08:02

Melanocortin-4 Receptor STEP Reporter Assay Kit (Luminescence)

Product Description

Stability : 1 year
Storage : -20°C
Description :
Melanocortin-4 receptor (MC4R) has important roles in weight regulation, sexual function, and inflammation. Mice deficient in MC4R have increased lipid deposition associated with elevated adiposity, while mutations in MC4R in humans are associated with early onset or severe obesity. Mice treated with a selective MC4R agonist have increased sexual function that is not observed in MC4R-null mice and central injection of an MC4R antagonist impairs male sexual behavior. Selective MC4R activation has been linked with the suppression of fever and reduced production of inflammatory mediators.

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