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Last modified
05/26/2018 - 08:48

MyD88 Polyclonal Antibody

Product Description

Formulation : 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Stability : 1 year
Storage : -20°C
Description :
WB · MyD88, a protein involved in interleukin-1 (IL-1) mediated signaling, was originally isolated as myeloid differentiation primary response gene.1,2 MyD88 possesses an N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and toll receptors. Overexpression of MyD88 induces activation of the c-Jun N-terminal kinase and NF-κB through its death domain.3,4 The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-κB activation induced by IL-1, but not by TNF. 

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