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Last modified
05/26/2018 - 08:52

NF-κB (p50) NLS Inhibitory Peptide Set

Product Description

Formulation : A lyophilized solid
Stability : 1 years
Storage : -20°C
Description :
The nuclear localization signal (NLS) sequence is required for nuclear translocation of NF-κB (p50). In un-stimulated cells, NF-κB is in the cytoplasm in an inactive form and the NLS is masked. The degradation of IkBa during NF-κB signaling unmasks the NLS of NF-κB subunits and NF-κB is translocated to the nucleus. The p50 inhibitory peptide contains the (p50) NLS sequence (VQRKRQKLM) and blocks the intracellular recognition mechanism for the NLS present on p50. Consequently p50 nuclear translocation is blocked.1 The (p50) NLS inhibitory peptide also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2 The control peptide consists of only the PTD sequence. 

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