Last modified
05/26/2018 - 09:09


Product Description

CAS Number : 337307-06-9
Molecular Formula : C49H44F2N4O5S
Formula Weight : 839.0g/mol
Specification :
Formulation:A crystalline solid
Stability:2 years
Description :
The 85 kD cytosolic phospholipase A2 (cPLA2 α) selectively hydrolyzes arachidonic acid from the sn-2 position of membrane phospholipids, generating substrate for eicosanoids and platelet-activating factor.1 RSC-3388 is a pyrrolidine derivative that acts as a potent inhibitor of cPLA2α, suppressing both recombinant human cPLA2 in vitro (IC50 = 1.8 nM) and cellular PLA2 activity in cells stimulated with the calcium ionophore A23187 (IC50 = 22 nM). In the human acute monocytic leukemia cell line THP-1, RSC-3388 blocks the production of prostaglandin E2 (IC50 = 31 nM) and leukotriene C4 (IC50 = 13 nM).2 RSC-3388 also reduces skin inflammation in murine models of atopic dermatitis, presumably through its inhibitory effects on cPLA2.3 
Storage : -20°C

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