Last modified
05/26/2018 - 08:42

SU 11652

Product Description

CAS Number : 326914-10-7
Molecular Formula : C22H27ClN4O2
Formula Weight : 414.9g/mol
Specification : 
reduces angiogenesis induced by estrogen in mice.3 
Formulation:A crystalline solid
Stability:2 years
Description :
Several growth factor receptors (GFRs) act as receptor tyrosine kinases (RTKs). Ligand binding triggers autophosphorylation of tyrosine residues on intracellular portions of the receptor, potentiating signaling to cause the growth response. SU 11652 is a potent, cell-permeable, and ATP-competitive inhibitor of the tyrosine kinase activity of several GFRs, including platelet-derived GFR (PDGFR-β; IC50 = 3 nM), vascular endothelial GFR (VEGFR-2; IC50 = 27 nM), and fibroblast GFR (FGFR1; IC50 = 170 nM), but not epidermal GFR (EGFR; IC50 > 20 μM).1 SU 11652 also potently inhibits wild-type Kit in mast cells (IC50 = 50 nM) and stops cell cycling while inducing apoptosis in cells expressing constitutively-active Kit mutants.2 Furthermore SU 11652
Storage : -20°C

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