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Last modified
05/26/2018 - 02:43

Toll-Like Receptor 5 Monoclonal Antibody (Clone 85B152.5)

Product Description

Stability : 1 year
Storage : -20°C
Formulation :
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
Description :
Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. TLR5 expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. TLR5 thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. 

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