25 Years Of Pharmaceuticals and Healthy&Cosmetic Ingredients Manufacturer & Supplier & Exporter.

Last modified
05/26/2018 - 08:45

YK-4-279

Product Description

CAS Number : 1037184-44-3
Molecular Formula : C17H13Cl2NO4
Formula Weight : 366.2g/mol
Specification :
Formulation:A crystalline solid
Purity:≥98%
Stability:2 years
Description :
ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5 to 2 µM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.1 
Storage : -20°C

Send inquiry online For more product information and prices

(Pharmaceutical Ingredients Manufacturer & Supplier & Exporter.)

After sending the online inquiry, we will reply you as soon as possible, if not get any response on time please contact us by Tel or Email. —— Green Stone Swiss

Email: [email protected]
Tel: +86 592 5365887
WhatsApp: +86 189 6515 7632
Send inquiry online: