15-hydroxy Prostaglandin Dehydrogenase (human recombinant)

CAS : 78028-01-0 
Molecular Formula : C17H16N2O5
Formula Weight : 328.32g/mol
Stability : 6 months
Formulation :
A solution in 50 mM Tris-HCl, pH 7.5, containing 1 mM EDTA, 1 mM DTT, and 30% glycerol
Description :
Human NAD+-dependent 15-PGDH is a 266 amino acid protein with a molecular weight of 29 kDa and is expressed in multiple tissues including lung, placenta, and kidney. The enzyme belongs to a large family of short-chain alcohol dehydrogenases, which exhibit amino acid identity ranging from 15-30%.3,4 Recent studies indicate 15-PGDH may play a role as a tumor suppressor. Studies have shown an inverse correlation between 15-PGDH expression and cell proliferation in colon, breast, and thyroid cells. 15-PGDH specific activity was determined using PGE2 as the substrate and NAD+ as the cofactor and was calculated after subtracting the mass contribution form the GST tag. The reaction was inhibited using CAY10397. 
Purity : >95% by SDS-PAGE
Storage : -80°C